Regulation of transcription in cancer.

Nuclear Architecture and Epigenetics of Lineage Choice

Differentiation is an epigenetic process which is installed by changes of transcriptional programs over successive cellular divisions. A number of studies have reported the effects of biochemical modifications of chromatin (DNA and chromatin proteins) on the regulation of transcription. Although, these studies are able to explain how transcription of a given gene is regulated (toward activation...

بیان ژن MALAT1 بعنوان یک نشانگر زیستی جدید در بیولوژی سرطان

Background & Aim: Long non-coding RNAs are regulatory molecules that adjust many vital intracellular processes. MALAT1 is a long non-coding RNA playing a key role in the regulation of intracellular important processes and also involved in biology of various cancers. The purpose of this study was to investigate the functions of MALAT1 and overview of its role in cancer biology. Methods: in this...

Investigating FGF11 gene transcription level in cancer cells among colorectal cancer patients

Background: Colorectal cancer (CRC) is the fourth leading cause of cancer-caused death around the world. Reports of the unnecessary transcription of family genes of the fibroblast growth factor in several types of cancer indicate the role of these factors in tumorgenesis and progression of cancer. Therefore, the level of FGF11 transcription was evaluated in colorectal cancer tumor tissues relat...

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

The Role of Tumor Protein 53 Mutations in Common Human Cancers and Targeting the Murine Double Minute 2–P53 Interaction for Cancer Therapy

The gene TP53 (also known as protein 53 or tumor protein 53), encoding transcription factor P53, is mutated or deleted in half of human cancers, demonstrating the crucial role of P53 in tumor suppression. There are reports of nearly 250 independent germ line TP53 mutations in over 100 publications. The P53 protein has the structure of a transcription factor and, is made up of several domains. T...

Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer

  Objective(s): Breast cancer is the most common type of cancer among women worldwide. This study investigated the expression and clinical significance of activating transcription factor 3 (ATF3) in human breast cancer and its relationship with the clinical outcome of breast cancer.   Materials and Methods : ATF3 expressions were detected in 114 primary breast cancer tissues and ...